| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Adrien Brody | Jack Driscoll | M1928 Thompson | - |
| Andy Serkis | Lumpy | M1928A1 Thompson | - |
| Bruce Cabot | Jack Driscoll | Smith & Wesson Model 10 | - |
| Charles Grodin | Fred Wilson | Star Model B | - |
| Ed Lauter | Carnahan | Colt Python | - |
| Evan Parke | Ben Hayes | Colt 1911A1 Pistol | - |
| Evan Parke | Ben Hayes | M1928 Thompson | - |
| Jack Black | Carl Denham | M1928 Thompson | - |
| Jack Black | Carl Denham | Mauser Gewehr 1898 | - |
| Jack O'Halloran | Joe Perko | Winchester Model 1897 Riot Gun | - |
| Jamie Bell | Jimmy | M1928 Thompson | - |
| Jamie Bell | Jimmy | Mauser Gewehr 1898 | - |
| Jeff Bridges | Jack Prescott | Remington Model 760 | scoped |
| Julius Harris | Boan | Marlin Model 336 | w/ scope |
| Kyle Chandler | Bruce Baxter | M1928 Thompson | - |
| Mario Gallo | Timmons | Remington Model 760 | - |
| Peter Jackson | Gunner | Lewis gun | Mounted on Curtis Falcon biplane |
| Robert Armstrong | Carl Denham | Lee-Speed Sporter | - |
| Thomas Kretschmann | Capt. Englehorn | M1928 Thompson | - |
| Thomas Kretschmann | Capt. Englehorn | Luger P08 | Artillery model |
| Thomas Kretschmann | Capt. Englehorn | Harpoon Gun | - |