| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Leslie Uggams | Blind Al | Steyr AUG | - |
| Leslie Uggams | Blind Al | Colt Model 1908 Vest Pocket | - |
| Leslie Uggams | Blind Al | Franchi PA3/215 | - |
| Morena Baccarin | Vanessa | Colt Model 1908 Vest Pocket | extended scene |
| Panuvat Anthony Nanakornpanom | Ajax's mercenary | SIG SG 552 | w/EOTech sight |
| Ryan Reynolds | Wade Wilson/Deadpool | Desert Eagle Mark XIX | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Para-Ordnance P-14 | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Colt Model 1908 Vest Pocket | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Smith & Wesson Model 29 | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Glock 17 | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Heckler & Koch Mark 23 | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Norinco Type 84S-2 | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Heckler & Koch MP5K | - |
| Ryan Reynolds | Wade Wilson/Deadpool | IMI Mini Uzi | - |
| Ryan Reynolds | Wade Wilson/Deadpool | Remington 870 | Police Folder pistol grip, top folding stock, TacStar front pistol grip. |
| T.J. Miller | Weasel | Remington 870 | - |
| T.J. Miller | Weasel | Steyr AUG | - |