| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Tom Cruise | IMF Agent Ethan Hunt | Beretta 92FS Brigadier | - |
| Tom Cruise | IMF Agent Ethan Hunt | Beretta 92FS Centurion | - |
| Tom Cruise | IMF Agent Ethan Hunt | Heckler & Koch USP | - |
| Tom Cruise | IMF Agent Ethan Hunt | M26 hand grenade | - |
| Dominic Purcell | Ulrich | Steyr GB | - |
| Dougray Scott | Sean Ambrose | Beretta 92FS Brigadier | - |
| Dougray Scott | Sean Ambrose | Sphinx AT 2000P | - |
| Richard Roxburgh | Hugh Stamp | Vektor CP1 | - |
| Ving Rhames | Luther Stickell | Beretta 92FS Inox | - |
| Ving Rhames | Luther Stickell | Colt Model RO635 9mm Submachine Gun | C-More sight and brass catcher |
| Ving Rhames | Luther Stickell | DPMS M-37 | Flare launcher, fitted to M4-type lower |
| William Mapother | Wallace | Vektor CP1 | - |