| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Tom Cruise | Nathan Algren | Winchester Model 1873 | Trapper model |
| Tom Cruise | Nathan Algren | Colt 1871-72 Open Top | - |
| Tom Cruise | Nathan Algren | Smith & Wesson Schofield | - |
| Tom Cruise | Nathan Algren | Enfield Pattern 1853 | - |
| Billy Connolly | Sergeant Zebulon Gant | Winchester Model 1873 | - |
| Hiroyuki Sanada | Ujio | Colt 1872 Open Top | - |
| Tony Goldwyn | Col. Bagley | Single Action Army | - |
| William Atherton | Mr. McCabe | Winchester Model 1873 | - |
| Yuki Matsuzaki | A Japanese soldier | Mauser Gewehr 1871 | - |