| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Tom Cruise | IMF Agent Ethan Hunt | Heckler & Koch G36K | - |
| Tom Cruise | IMF Agent Ethan Hunt | Heckler & Koch MP5K | with PDW-style stock |
| Tom Cruise | IMF Agent Ethan Hunt | Barrett M82A1 | - |
| Tom Cruise | IMF Agent Ethan Hunt | Beretta 92FS | - |
| Tom Cruise | IMF Agent Ethan Hunt | Glock 17 | - |
| Tom Cruise | IMF Agent Ethan Hunt | Desert Eagle | - |
| Billy Crudup | Musgrave | Beretta 92FS | - |
| Jonathan Rhys Meyers | Declan | Glock 17 | - |
| José Zúñiga | Pete | Ruger Mk I | modified to fire taser darts |
| Keri Russell | IMF Agent Lindsey Ferris | Beretta 92F | Surefire Tactical light |
| Keri Russell | IMF Agent Lindsey Ferris | M4A1 | - |
| Maggie Q | Zhen | Heckler & Koch UMP-45 | - |
| Maggie Q | Zhen | Glock 17 | - |
| Michelle Monaghan | Julia | Beretta 92FS | - |
| Philip Seymour Hoffman | Owen Davian | SIG-Sauer P228 | compensator |
| Philip Seymour Hoffman | Owen Davian | Beretta 92FS | - |
| Philip Seymour Hoffman | Ethan Hunt posing as Owen Davian | Glock 17 | modified to fire tranquilizer darts |
| Timothy Omundson | IMF Agent | Ruger Mk I | modified as Taser-style weapon |
| Ving Rhames | Luther Stickell | Heckler & Koch P2A1 Flare Pistol | - |
| Ving Rhames | Luther Stickell | Barrett M82A1 | remotely controlled |