| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Tom Cruise | Roy Miller | SIG-Sauer P250 | - |
| Tom Cruise | Roy Miller | Heckler & Koch MP7 | - |
| Tom Cruise | Roy Miller | Glock 19 | - |
| Tom Cruise | Roy Miller | Heckler & Koch P2000 | - |
| Tom Cruise | Roy Miller | SIG-Sauer P229 | - |
| Tom Cruise | Roy Miller | Taurus Judge | - |
| Tom Cruise | Roy Miller | Springfield Armory TRP | - |
| Tom Cruise | Roy Miller | Z-M LR 300ML | - |
| Cameron Diaz | June Evans | Glock 19 | - |
| Cameron Diaz | June Evans | Heckler & Koch MP7 | - |
| Cameron Diaz | June Evans | SIG-Sauer P250 | - |
| Dane Farwell | Pilot | Heckler & Koch USP Expert | - |
| Jordi Mollà | Antonio Quintana | Beretta 92G Elite II | - |
| Peter Sarsgaard | Fitzgerald | SIG-Sauer P226 | - |
| Rich Manley | Danny | SIG-Sauer P229 | - |
| Trevor Loomis | Eduardo | Beretta 93R | - |
| Trevor Loomis | Eduardo | AKMS | - |