| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Tom Cruise | IMF Agent Ethan Hunt | SIG-Sauer P226R | suppressed |
| Tom Cruise | IMF Agent Ethan Hunt | Disguised Rifle | - |
| Jens Hultén | Janik Vinter | AKS-74U | - |
| Jens Hultén | Janik Vinter | Heckler & Koch HK4 | - |
| Rebecca Ferguson | Ilsa Faust | SIG-Sauer P226R | Suppressed |
| Rebecca Ferguson | Ilsa Faust | Heckler & Koch USP Compact | Suppressed |
| Sean Harris | Solomon Lane | SIG SP 2022 | suppressed |
| Sean Harris | Solomon Lane | Heckler & Koch USP Compact | - |
| Simon McBurney | Atlee | Walther SSP-E | used as tranq gun |