| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Tom Cruise | IMF Agent Ethan Hunt | SIG-Sauer P226R | Deleted scene only |
| Tom Cruise | IMF Agent Ethan Hunt | Heckler & Koch USP Compact | - |
| Tom Cruise | IMF Agent Ethan Hunt | Colt M1911A1 | - |
| Tom Cruise | IMF Agent Ethan Hunt | Baikal IJ-70 | - |
| Alec Baldwin | Alan Hunley | Jericho 941 | - |
| Alix Bénézech | Paris Police Officer | SIG Pro SP 2022 | - |
| Henry Cavill | August Walker | FN Minimi SPW | - |
| Henry Cavill | August Walker | Jericho 941R | - |
| Liang Yang | Lark | Baikal IJ-70 | - |
| Rebecca Ferguson | Ilsa Faust | Heckler & Koch USP Compact | - |
| Rebecca Ferguson | Ilsa Faust | SIG-Sauer P226 | - |
| Rebecca Ferguson | Ilsa Faust | Heckler & Koch HK416C | - |
| Simon Pegg | Benji Dunn | SIG SG 552 | - |
| Simon Pegg | Benji Dunn | Jericho 941F | - |
| Simon Pegg | Benji Dunn | SIG-Sauer P226R | - |