| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Tom Cruise | IMF Agent Ethan Hunt | SIG SG 552 | C-More sight |
| Tom Cruise | IMF Agent Ethan Hunt | M1911 | - |
| Esai Morales | Gabriel | Walther PPK | - |
| Greg Tarzan Davis | Degas | SIG-Sauer P228 | - |
| Pom Klementieff | Paris | Heckler & Koch HK416 | ACOG Scope |
| Pom Klementieff | Paris | SIG-Sauer P226R | - |
| Rebecca Ferguson | Ilsa Faust | Accuracy International AX308 | Suppressed |
| Rebecca Ferguson | Ilsa Faust | M4A1 | ACOG sight |
| Shea Whigham | Jasper Briggs | SIG-Sauer P228 | - |