| Smith and Wesson Model 36 |
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| Smith and Wesson Schofield |
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| Smoke Grenade |
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| Smoke grenade |
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| Smython |
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| Snider Enfield Cavalry Carbine |
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| Snider-Enfield Cavalry Carbine |
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| Snider-Enfield Mk. II** Short Rifle |
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| Snider-Enfield Mk.II** Infantry |
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| Snider-Enfield Rifle |
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| Sniper rifle |
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| Snub nose revolver |
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| Snubnose revolver |
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| Solothurn ITM AT84S |
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| Sonic Disruptor |
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| Sonn-Blas F-11D Blaster Rifle |
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| Sonn-Blas SE-44C Blaster Pistol |
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| Sound & Flash 9 Bang |
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| Spanish Mauser 1895 Carbine |
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| Spanish Mauser M1893 |
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| Spear Gun |
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| Spear gun |
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| Speargun |
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| Special "Henry" rifle |
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| Special Weapons SP-10 |
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| Special gun in gameeXistenZ |
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| Spectre M4 |
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| Spectre-HC |
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| Spencer 1860 |
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| Spencer 1860 Carbine |
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| Spencer 1882 |
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| Sphinx 3010 |
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| Sphinx 3010 Standard |
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| Sphinx AT 2000P |
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| Sphinx AT-2000 |
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| Sphinx AT-2000P |
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| Sphinx AT-380 |
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| Sphinx AT380 |
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| Sphinx AT380M |
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| Spike Gun |
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| Spike's Tactical Compressor |
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| Spike's Tactical Havoc Launcher |
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| Spitfire Carbine |
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| Spitfire Submachine Gun |
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| Sporter rifle |
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| Sporterized 1909 Argentine Mauser |
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| Sporterized Lee-Enfield No. 1 Mk III |
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| Sporterized M1903 Springfield |
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| Sporterized Mauser 1893 or 1895 |
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| Sporterized Mauser Rifle |
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