| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Barbara Carrera | Maria | M1917 Enfield | - |
| Burt Lancaster | Dr. Paul Moreau | Mauser Gewehr 1898 | With shoulder strap |
| Burt Lancaster | Dr. Paul Moreau | Enfield No. 2 | Mk. 1* with 5" barrel and wooden grips |
| David Thewlis | Kevin | Beretta 92FS Inox | - |
| David Thewlis | Kevin | Webley & Scott No. 4 Mk. I | - |
| David Thewlis | Kevin | Norinco Type 56 | - |
| Marlon Brando | Dr. Moreau | Captive Bolt Pistol | - |
| Michael York | Andrew Braddock | Enfield No. 2 | - |
| Michael York | Andrew Braddock | M1917 Enfield | - |
| Nigel Davenport | Montgomery | M1917 Enfield | - |
| Nigel Davenport | Montgomery | Webley Army Model | - |
| Temuera Morrison | Azazello | Heckler & Koch VP70 | - |
| Temuera Morrison | Azazello | Beretta 84F | - |
| Temuera Morrison | Azazello | Captive Bolt Pistol | - |
| Val Kilmer | Dr. Montgomery | Beretta 92FS Inox | - |
| Val Kilmer | Dr. Montgomery | Heckler & Koch VP70 | - |
| Val Kilmer | Dr. Montgomery | Sam Yang Air Rifle | - |