| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Brad Pitt | Jesse James | Single Action Army | "Artillery" and "Cavalry" models |
| Brad Pitt | Jesse James | Smith & Wesson Schofield | - |
| Casey Affleck | Bob Ford | Single Action Army | - |
| Casey Affleck | Bob Ford | Colt Paterson | - |
| Casey Affleck | Bob Ford | Smith & Wesson New Model No.3 | - |
| Casey Affleck | Bob Ford | Smith & Wesson Schofield | - |
| Garret Dillahunt | Ed Miller | Double Barreled Shotgun | - |
| Garret Dillahunt | Ed Miller | Single Action Army | - |
| Jeremy Renner | Wood Hite | Single Action Army | - |
| Michael Copeman | Edward O'Kelley | 12 Gauge Double Barreled Shotgun | - |
| Paul Schneider | Dick Liddil | Colt 1851 Navy | - |
| Paul Schneider | Dick Liddil | Colt Paterson | - |
| Sam Rockwell | Charley Ford | Single Action Army | - |
| Sam Shepard | Frank James | Remington 1875 | - |
| Ted Levine | Sheriff James Timberlake | Smith & Wesson Schofield | Uberti replica, "Well's Fargo" model with blued finish and wooden grips |