| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Cary-Hiroyuki Tagawa | Lieutenant A.J. Shimamura | Beretta 92FS | - |
| Cheech Marin | Inspector Joe Dominguez | Ruger P89 | - |
| Cheech Marin | Inspector Joe Dominguez | Smith & Wesson SW99 | - |
| Don Johnson | Inspector Nash Bridges | M1911A1 | Two tone; customized |
| Jaime Gomez | Inspector Evan Cortez | Smith & Wesson 659 | - |
| Jeff Perry | Inspector Harvey Leek | Glock 17 | - |
| Jodi Lyn O'Keefe | Cassidy Bridges | Beretta 9000S | - |
| Kelly Hu | Inspector Michelle Chan | Glock 17 | - |