| Actor | Character | Firearm | Notes |
|---|---|---|---|
| Gary Oldman | DEA Agent Norman Stansfield | Ithaca 37 | pistol grip, flashlight |
| Gary Oldman | DEA Agent Norman Stansfield | Smith & Wesson Model 629 Snub | fitted with 3 inch barrel and unfluted cylinder |
| Jean Reno | Leon | Beretta 92F | with compensator |
| Jean Reno | Leon | Smith & Wesson Model 586 | - |
| Jean Reno | Leon | F-1 Firearms BDR-15-3G | - |
| Jean Reno | Leon | Spectre M4 | seen in the extended cut |
| Michael Badalucco | Mathilda's father | Remington 870 Slug Gun | - |
| Peter Appel | Malky | Ithaca 37 | - |